Latest update diXa Data Warehouse


"The diXa data infrastructure (www.dixa-fp7.eu/) harbours the 'omics data from all EU FP6/FP7 toxicogenomics projects, as well as from Open TG-Gates and DrugMatrix, plus corresponding chemoinformatics data and molecular data on human diseases representing major endpoints of repeated dose toxicity. Coordination of diXa is with Maastricht University in The Netherlands while the data infrastructure itself is hosted by the European Bioinformatics Institute in the UK.

The Netherlands Toxicogenomics Centre, a private-public partnership of 8 Dutch academic toxicology groups and 12 companies (www.toxicogenomics.nl), has now also decided to submit its toxicogenomics data to the diXa infrastructure. Till date, data from 3795 mRNA arrays and 1057 microRNA arrays generated from 110 compounds have been uploaded. The research program of the Netherlands Toxicogenomics Centre is aimed at addressing current dilemmas in toxicology associated with the risk assessment of chemicals. There is a clear demand for new types of mechanism-based studies, not only to fill the current gaps of knowledge and to improve our understanding of the toxicological mode of action studies but also to develop efficient test protocols to bridge the gap between in vitro mechanism-based studies and in vivo empirical studies.

Recently data from the Predicti-IV EU project “Profiling the toxicity of new drugs: a non-animal-based approach integrating toxico-dynamics and biokinetics”project been uploaded (www.predict-iv.toxi.uni-wuerzburg.de/)

The diXa data warehouse is publicly accessible, click here.

Further readings: Hendrickx DM et al. diXa: a data infrastructure for chemical safety assessment. Bioinformatics. 2015 May 1;31(9):1505-7" click here.