dixa Open Conference

Date:      29-30 September 2014

Venue:   EMBL-EBI, Wellcome Trust Genome Campus
                Hinxton - Cambridge
                CB10 1SD

The diXa Open Conference and Hands-on Training Workshop of the EU FP7 diXa project took place on September 29-30, 2014 in Hinxton - Cambridge, United Kingdom (Partner EMBL - www.ebi.ac.uk).

The diXa project is dedicated to developing and implementing a robust and sustainable service
infrastructure for data from EU-funded research into ‘omics-based non-animal tests for predicting
chemical safety. After three years, the diXa project has delivered the final scientific report
and software portal.

The purpose of the diXa Open Conference was to share the scientific results of the project and to debate the latest advances and future challenges in Toxicogenomics. We have made the videos and slides of the talks (see programme) available to you in case you were unable to join us on the day.


Day 1     diXa Open Conference

09:30 - 10:00       Registration and Refreshments

10:00 - 10:10       Welcome

                                                Janet Thornton, EMBL - European Bioinformatics Institute


10:10 - 10.40       A data infrastructure for chemical safety: challenges and requirements

                                                Jos Kleinjans, diXa Coordinator, Maastricht University

                                                [video] [slides]

10.40 - 11.10       diXa Warehouse walk through

                                                John Overington, EMBL - European Bioinformatics Institute

                                                [video] [slides]

11:10 - 11:40       The chemical space within diXa

                                                Antonella Zanzi, EC Joint Research Centre (JRC)

                                                [video] [slides]

11:40 - 12:05       diXa Use Cases

                                                Ralf Herwig, Max Planck Institute for Molecular Genetics

                                                [video] [slides]

12:05 - 12:30       Cross work package diXa use case: exploring structure-activity relationships

                                                Dennie Hebels, Maastricht University

                                                [video] [slides]

12:30 - 13:30       Lunch

13:30 - 14:00       The eTox project

                                                Francois Pognan, Novartis

                                                [video] [slides]

14:00 - 14:30       Chemical safety and big data: the industry’s demands

                                                Richard Currie, Syngenta 


14:30 - 15:00       Coffee & Tea break

15:00 - 15:35       Perspective on future data requirements in biomedical research

                                                John Quackenbush, Harvard School of Public Health

                                                [video] [slides]

15:35 - 16:10       A critical evaluation of data infrastructures in the domain of drug development

                                                Mike Furness, DNAnexus


16:10 - 16:25       diXa training and servicing resources

                                                Vera Matser, EMBL - European Bioinformatics Institute

                                                 [video] [slides]

16:25 - 16:40       Short break

16:40 - 17:30       Panel Discussion ‘Current and future challenges in Toxicogenomics data management’

                                                Wolfgang Dekant, Editor-in-Chief Toxicology Letters

                                                Gary Miller, Editor-in-Chief Toxicological Sciences

                                                Joop de Knecht, OECD

17:30 - 19:30       Networking reception

Day 2     diXa hands-on training

09:00 - 09:30           Registration & refreshments

09:30 - 10:00           diXa data warehouse

                                                Vera Matser, EMBL - European Bioinformatics Institute

                                                Ekaterina Pilicheva, EMBL - European Bioinformatics Institute

10:00 - 12:00           Functional Genomics (Array Express & Expression atlas)

                                                Maria Keays, EMBL - European Bioinformatics Institute

12:00 - 12:30           Lunch

12:30 - 14:30           ChEMBL & SureChEMBL     

                                                Francis Atkinson, EMBL - European Bioinformatics Institute

diXa Open Conference and Hands-on Training Workshop  v2 diXa Open Conference and Hands-on Training Workshop v2 (2 Mb) Programme_dixa Programme_dixa (309 kb)