The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially more acceptable. For developing such assays, FP6/FP7 Research Programmes are exploiting the revenues of data-dense genomics technologies. However, till date, there is no infrastructure foreseen which aims at capturing all data produced by toxicogenomics (TGX) projects, in a standardized, harmonized and sustainable manner. Data may thus evaporate. The lack of such an infrastructure also prevents innovative breakthroughs from meta-analyses of joint databases and systems modeling. The diXa projects thus responds to the needs the EU Toxicogenomics Research Community, active in exploring cellular technologies and data-dense ‘omics technologies in combination with advanced bioinformatics and biostatistics, for the purpose of developing non-animal tests for chemical safety, for a robust and openly accessible data infrastructure for capturing toxicogenomics data and for the deployment of services with regard to data generation, to procedures for harmonization and standardization of toxicogenomics data, as well as to customized tools and techniques for advanced statistics and modeling. read more >

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Registration for the diXa course “Small molecules, gene products and their interaction”

Registration for the diXa course “Small molecules, gene products and their interaction - EBI Roadshow, Pathway-Network course and diXa Training Course ”, 1-5 July 2013, Maastricht is now open.
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Research article of interest – May 2013

“Web-scale pharmacovigilance: listening to signals from the crowd”. Paper from White et al, 2013 demonstrates the potential value of using patient internet search behaviour as an additional signal for pharmacovigilance.
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